In Vivo Evaluation of a Fully-Passive Wireless Neurosensing System

Neural implants are used to continuously record essential signals in studies of neurological disorders. Existing systems involve the use of invasive procedures and revision surgeries to maintain adequate system performance. Our previous work demonstrated a fully-passive wireless system, tested in vitro, and was demonstrated capable of sensing even minute neural signals. This recorder has a minimum detectable signal (MDS) below 15 μV in amplitude and a RF sensitivity down to about - 135 dBm. While results have been promising, this system is yet to be used to study neurological disorders, the final intended application of the system. In this paper, for the first time, we evaluate the wireless neurosensing system's ability to capture the characteristic components of epilepsy, namely interictal epileptiform discharges. The present validation of this technology has great future clinical implications in neuroscience, especially epilepsy studies.