Ultrasound-Tagged Chemiluminescence Tomography in Turbid Media

Ultrasound assisted hybrid technique for optical imaging being available for biomedical tomography is proposed. Ultrasonic tagging on chemiluminescence (CL), which is derived by sonochemical effect of CL reaction, is applied for CL imaging in light scattering media. We have developed a tomographic imaging system equipped with an ultrasound phased-array transducer for electronic scanning of the ultrasound focus. The imaging performance using a body phantom including a luminol CL target was demonstrated, suggesting the potential for tomographic imaging of biological function with mm resolution in living bodies.