Non-Invasive Measurement of Glaucoma Disease at Earlier Stage Through GMR Sensor AH Biomagnetic Signal From Eye and RADWT Algorithm

In this paper, we propose a non-invasive method to detect glaucoma eye disease at the earlier stage from aqueous humor (AH) fluid’s biomagnetic signal in anterior chamber of eye. The AH fluid has biomagnetic emission because of magnetic material, such as sodium, potassium, chloride, bicarbonate, and protein. At present, the diagnosis of glaucoma was done at the later stage because of undetectable microvariation in the fundus image cup to disc size ratio measurement and because of similar symptoms in glaucoma eye and vision problem. In the proposed method, glaucoma can be detected through the acquisition of AH fluid biomagnetic signal from eye through giant magnetoresistance magnetometers (GMRs) sensor. The biomagnetic signal of AH fluid’s dynamic and static variation in eye is analyzed with the rational dilation wavelet transform (RADWT) algorithm. The variations of AH fluid is obtained through beta-blocker eye drops. From experiment, The AH fluid’s biomagnetic signal shows variations for the rate of dissipation of fluid in eye, such as normal and glaucoma eye, with and without eye drops. The AH biomagnetic signal correlates glaucoma disease with signal variance and RADWT subband energy for 50 glaucoma and 10 normal eye. The proposed method detect glaucoma eye in the early stage with 90% accuracy. The experimental result is validated with glaucoma measuring tonometer instrument. The earlier detection of glaucoma eye is measured through regression modeling.