Label-free Biomolecular Sensing by SERS on Nanoporous Gold Nanoparticle Arrays

We review our recent progress in surface-enhanced Raman scattering (SERS) biomolecular sensing on substrate-bound nanoporous gold (NPG) nanoparticles arrays which feature large surface area, tunable plasmonics, and high-density localization of enhanced electric field. This type of SERS substrate has been shown to provide superior performance in terms of ultrahigh sensitivity and reliable specificity for robust detection.