Optofluidic and Electrochemical Nanoslits for Rapid Measurement of Receptor Binding to Neuropeptides

A novel nanoscale optofluidic and electrochemical platform for rapidly screening receptors based on their binding to key neuropeptide targets is reported. The nanoslit structures dramatically reduce the diffusion length of target analytes, thereby enhancing collision frequencies with receptors and enabling rapid measurement of chemical binding constants, with minimal diffusional dependence.