The Study on Fabrication of Solid Metal Microneedles Based on Optimized Process of Electrochemical Etching and Cutting

The use of microneedles to transport drugs to organisms is an important way of transdermal delivery, and the preparation of microneedles is the key to its realization. In this paper, metal microneedles are prepared through a combined method of cutting and electrochemical etching whose parameters are optimized as well. It is studied first in the paper the influences of the electrochemical machining parameters, which is optimized as well, on the shape of metal microneedles, and then the influences of the cutting method on the rough shape of the stainless-steel needle bodies. The conical shape is easily to be obtained through cutting with bevel-cutting tools. A short time will elapse for forming sharply-tipped needles with a uniform shape by electrochemical etching method.