Thermal Analysis of Superparamagnetic Nanoparticles Subject to an Alternating Magnetic Field

This paper presents the thermal analysis of superparamagnetic (SPM) nanoparticles used for hyperthermia of cancer tumor. Hyperthermia, heating disease sites to 42°C-45°C to cause cancer cell damage or death without harm to the normal cells or tissue, is a promising mode of adjuvant cancer therapy intended to enhance the efficacy of traditional therapies such as radiotherapy and chemotherapy. In order to effectively kill cancerous cells in the limited small temperature range, the accurate temperature control plays an important role on therapeutic efficacy and quality. The past theoretical study on this topic mainly focused on the models for the hysteresis loss-induced heat generation in SPM nanoparticles subject to an alternating magnetic field. Few papers theoretically analyzed the temperature in SPM nanoparticles. Therefore it is essential to theoretically predict the temperature in SPM nanoparticles subject to an alternating magnetic field for hyperthermia of cancer tumor. And the influences of material and magnetism parameters on the temperature in SPM nanoparticles will be also discussed.