Design of cybernetic model for glucose clamp techniques

Glucose clamp techniques are used in clinical studies to determine glucose metabolism indices. In order to “clamp”the blood glucose levels, the negative feedback principle is used to maintain glycemia at desired levels, depending on the specific clamp technique. The purpose of this study is to develop dynamical multivariable system model of glucose metabolism for analysis of input/output interactions using cybernetic principles. The structure of model is chosen to study the direct impact of insulin and glucose infusion rate on glucose and insulin levels in blood. The model is derived from the linearization of widely used Bergman minimal model. Multiple input-output interaction can then be further analyzed in order to determine the quality and robustness of existing control strategies or to develop new ones Simulations of a more complex physiological Sorensen model are used to validate the resulting model.