Scale-bundle spline-based non-rigid registration for handling fissures

We introduce a novel scale-bundle approach for spline-based non-rigid registration and handling of large semi-global deformations in histology images due to tissue fissures. Our approach is based on a scale-bundle physical deformation model in conjunction with a novel intensity-based similarity metric. Small local deformations as well as large semi-global deformations can be effectively handled. We applied our method to multi-modal 3D polarized light imaging data of histology sections of the human brain. We performed a quantitative and qualitative assessment of our approach using different sections of the temporal lobe which include fissures.