Using EWOD chip for the culture medium movement and dynamic culture of mouse embryos

In this paper, EWOD (Electro-wetting on dielectric) system is used in reproductive medicine and has been expected to be a dynamic cell culture platform for assisted reproductive technology (ART). The EWOD device is anticipated to provide a stable culture environment and improve the growth environment of mouse embryos based on its advantages of uniform hormone mixing in the culture medium. As we predicted, the development rate of embryos cultured by dynamic process is better than embryos of static group. Although the development rate of the chip group is slightly worse than the control group, the biocompatibility of EWOD and the potential of EWOD chip for delivering biological cells and cells culture has been confirmed.