A hybrid model to predict proteins tertiary structure

In this paper, we study the impact of using a hybrid-technique approach, which is a combination of genetic algorithm (GA) and protein's free energy minimization calculations, to predict protein tertiary structure. We compare the results with a basic approach which applies genetic algorithm only. A genetic algorithm is used to predict the protein structure using the primary structure, the amino acids sequence of a given polypeptide chain, as input. After that, we combine the GA with energy minimization feature. Finally, the outcomes of both experiments are analyzed. Results reveal that the hybrid approach outperforms the basic one.