Symetries and asymetries of the immune system response: A categorification approach

A new modeling approach and conceptual framework to the immune system response and its dual role with respect to cancer is proposed based on Applied Category Theory. States of cells and pathogenes are structured as mathematical structures (categories), the interactions, at a given phase, between cells of the immune system and pathogenes, correspond to a pair of adjunctions (adjoint functors), the interaction process consisting of the sequential composition of an identification phase, a preparation phase and an activation phase is modeled by the composition of maps of adjunctions: the approach is illustrated by considering the Cancer-Immunity Cycle. A third dimension is needed to model Cancer Immunoediting. The categorical foundations of our approach is based on Marco Grandis and Rober Paré theory of Intercategories.