Mechanism investigation, device development, and treatment personalization using anatomical models functionalized with electrophysiological neuron models

By functionalizing high resolution anatomical models with electrophysiologically and morphologically detailed neuron models in anatomically realistic positions, it becomes possible to investigate the interaction of externally or internally applied electromagnetic fields with neuronal dynamics. This has been successfully applied for mechanistic elucidation, safety assessment, therapeutic device development and optimization, as well as treatment personalization related to the fields of neuroprosthetics, neurostimulation, electroceuticals, and magnetic resonance imaging (MRI). Some of the functionalized anatomical model predictions have already been experimentally validated, but additional measurements and more comprehensive functionalization, e.g., with major peripheral nerves, are required and planned.