Validity of the Keller-Miksis equation for “non-stable” cavitation and the acoustic emissions generated

The Keller-Miksis equation (KME) is commonly used for numerical studies of inertial and stable-inertial cavitation. However, experimental validation of KME under clinically relevant exposure settings is scarce, particularly in terms of the acoustic emission signal generated by the cavitation. Validation of KME for strongly driven bubbles could significantly aid the design of arrays for passive acoustic mapping (PAM), quantification of cavitation dose, and the study of novel cavitation configurations such as dual-frequency exposures and control systems.