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High resolution ultrafast imaging of microbubble destruction during sonoporation | IEEE Conference Publication | IEEE Xplore

High resolution ultrafast imaging of microbubble destruction during sonoporation


Abstract:

Ultrasound-mediated drug delivery using microbubbles is a growing field with applications ranging from targeted chemotherapy delivery to permeating the blood brain barrie...Show More
Notes: This document is the abstract for the above title. To access the full conference paper please go to: 10.1109/ULTSYM.2017.8092568

Abstract:

Ultrasound-mediated drug delivery using microbubbles is a growing field with applications ranging from targeted chemotherapy delivery to permeating the blood brain barrier. However, the precise parameters that induce increased cellular permeability are not fully understood. For sonoporation efficiency, a high microbubble concentration is preferred, but acoustic shadowing limits the ultrasound delivery to the cells. Our hypothesis is that high-resolution ultrafast imaging will demonstrate the interaction of ultrasound with microbubbles during the sonoporation process to carefully control the ultrasound dose. This work has two aims: 1) to accurately image the ultrasound delivery to cells with high-resolution ultrafast imaging, and 2) to determine the dependence of microbubble concentration and acoustic environment on cavitation activity. This will lead to optimization of sonoporation.
Notes: This document is the abstract for the above title. To access the full conference paper please go to: 10.1109/ULTSYM.2017.8092568
Date of Conference: 06-09 September 2017
Date Added to IEEE Xplore: 02 November 2017
ISBN Information:
Electronic ISSN: 1948-5727
Conference Location: Washington, DC, USA