Electroporation of inhomogeneous samples: From conduction field to equivalent resistance

Electrochemotherapy (ECT) is a local therapy used in clinical practice. This therapy improves the drug uptake of tumor tissue since it permeabilizes cell membranes by means of an electric field. Nevertheless, the tumor tissue could be characterized by inhomogeneity areas and needle electrodes could be implanted in tissue with different values of conductivity. The authors investigate by means of numerical simulations and experimental tests the effect of tissue inhomogeneity which can affect the current density distribution.