CMOS-based opto-electric neural interface devices for optogenetics

In this study, CMOS-based on-chip neural interface devices with integrated optical stimulation capability are presented. The devices are designed for use in optogenetic applications. Two types of neural stimulators are presented. In one type, the on-chip CMOS image sensor was integrated with blue LEDs. Variations of device structures were developed as well. An in vivo experimental demonstration using a mouse was successfully performed. We also proposed and developed the structure of an opto-electric neural interface device with wide-area coverage. Multi-node device architecture including multiple CMOS chips is proposed for this type and its functionality is demonstrated.