A genetically-engineered polypeptide carrier for thermal targeting of therapeutics

Reports the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. The authors hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. The authors report preliminary in vivo results which support this hypothesis.