Complex conservative treatment of chronic tonsillitis in children using local immunostimulation (autologous mononuclear cells)

Introduction. The priority directions in pediatric otorhinolaryngology are development of diagnostic criteria in chronic tonsillitis in children and argumentation of complex conservative therapy tactics to preserve palatine tonsils as important organs in local and general immunity. Materials and methods. The study included 64 children with chronic tonsillitis who were divided into 2 groups: 32 children were applied standard treatment including local immunomodulatory therapy (group 1) and 32 children - only standard treatment (group 2). Results. After treatment, sensitivity of T lymphocytes to streptococcus antigens and total content of B lymphocytes decreased more pronouncedly in children of group 1. Indices of T lymphocyte functional activity were conclusively increased in children of group 1 compared to children of lot 2. Local immunostimulation reduces supranormal levels of proinflammatory cytokines TNF-α, IL-S and IL-1β and increase the low titers of anti-inflammatory cytokine IL-4. Conclusions. Local therapy with autologous mononuclear cells has a complex action upon the changes of immune reactivity state in children with chronic tonsillitis.