Application specific integrated circuit (ASIC) for Ion Sensitive Field Effect Transistor (ISFET) L-Asparagine biosensor

This work presents the design of application specific integrated circuit (ASIC) intended for L-Asparagine measurement, using ion sensitive field effect transistor (ISFET) as biosensor. The L-Asparagine is an amino acid that promotes the growth of cancer cells in leukemia patients. The designed ASIC is comprised of ISFET bridge-type readout circuit, inverting operational amplifier, and peak detector circuit. The L-Asparagine concentrations are translated into pH levels. SPICE simulations showed a sensitivity of -72.78 mV/pH with a linear correlation of almost 1 across the output of the designed ASIC.