A Lab-On-a-Chip front-end based on DeFET sensor array for biomedical analysis

This paper presents a new integrated Lab-On-a-Chip (LOC) based on Differential electric-field sensitive Field-Effect Transistor (DeFET) sensor array that is used in Biomedical Analysis. The proposed system introduces a 4 × 4 DeFET sensor array, analog multiplexer, readout circuit, and Analog to Digital Converter (ADC) that perform the sensing, actuating, and signal conditioning tasks. The proposed LOC is verified using circuit level simulation in the UMC 130 nm CMOS technology node. Simulation results show that the sensitivity of the DeFET sensor is appreciably enhanced. The proposed LOC consumes 2.2 mA from 1.2 V supply. Besides that, the equivalent circuit, and the theory of operation of the DeFET sensor are discussed.