Analysis of the effect of not-parallel needles in electroporation

In electrochemotherapy (ECT), flexible electrodes, composed by an array of needles, are applied to human tissues to treat large surface tumors. The positioning of the needles in the tissue is randomly determined and their relative inclinations strongly affect the actual distribution of electric field. This paper analyzes the effect of inclined electrodes, also in not-uniform tissues, by means of numerical models and experiments.