Enzyme-Free Scalable DNA Digital Design Techniques: A Review

With the recent developments in DNA nanotechnology, DNA has been used as the basic building block for the design of nanostructures, autonomous molecular motors, various devices, and circuits. DNA is considered as a possible candidate for replacing silicon for designing digital circuits in a near future, especially in implantable medical devices, because of its parallelism, computational powers, small size, light weight, and compatibility with bio-signals. The research in DNA digital design is in early stages of development, and electrical and computer engineers are not much attracted towards this field. In this paper, we give a brief review of the existing enzyme-free scalable DNA digital design techniques which are recently developed. With the developments in DNA circuits, it would be possible to design synthetic molecular systems, therapeutic molecular devices, and other molecular scale devices and instruments. The ultimate aim will be to build complex digital designs using DNA strands which may even be placed inside a human body.