Pulsatile blood flow through large arteries with BJR slip condition

Hemodynamics in large human arteries, both in systemic and pulmonary circulation, is analysed. To the best of our knowledge, in pulsatile flow, this is the first theoretical study elaborating on hemodynamic factors such as Wall Shear Stress, Oscillatory Shear Index, Relative Residence Time and their effects on the pathogenesis of atherosclerosis by employing BJR slip at the lumen-wall interface, which takes into account the finite wall thickness of the artery. Also, the physiological pressure gradient waveform taken from the medical literature is modeled realistically by using McDonald's model. All the results reported are in good agreement with the data given in the available medical literature. Our model can predict the biological response of the artery in the normal/abnormal flow regime in a much better way, if the data fixed are subject specific. Our results confirm that low WSS and high OSI need not co-locate and also, explain the significances of OSI and RRT in the formation of atherosclerosis. Further, it emphasizes the need for the appropriate slip condition at the lumen-wall interface in the context of blood flow.