Finite Element Modeling of Atherosclerotic Plaque Evolution

In this paper we considered a time-dependent coupled problem of the low-density lipoproteins (LDL) diffusion into internal layers of the blood vessel, diffusion of macrophages and deformation of the vessel wall with endothelial defects. Solving of the problem in its axisymmetric formulation is performed using finite element (FE) package Comsol Multiphysics in the framework of joint working modes: Convection/Diffusion (for the LDL), Diffusion (for the LDL modified by macrophages, or foam cells), and Moving Mesh (for visualizing the wall deformation).