Microelectrodes array technology: A review of integrated circuit biopotential amplifiers

Microelectrode arrays have extensive applications in the biomedical field. These applications range from the study of the influence of drugs in cell cultures to neuro-implants for attenuation of diseases, such as Parkinson's disease and epilepsy. The main block of the analog front-end attached to the MEA is the bioamplifier that amplifies biomedical potential signals. Different designs for this block are presented in literature and a comparison between them is needed to analyze the best performance possible when working with MEA systems. This review paper presents an overview on MEA systems, focusing on the bioamplifier and its components with the goal of providing a design suggestion that maximizes the performance of MEA signal acquisition.