Synergism of spectral and coupling modalities in epileptic focus localization from iEEG recordings

determining the epileptogenic zone (EZ) from intracranial electroencephalography (iEEG) recordings is an important but nontrivial task. In this pilot study we demonstrate the usefulness of phasesynchronized phase-amplitude coupling constellations as a hybrid construct from well-established phase-amplitude and phase-phase coupling measurements. Also, we introduce a heuristic measure related to spectral entropy which can further improve the specificity of EZ detection. Our analysis works on seizure-free sleep iEEG grid data abundant in a typical clinical setting and aside from the initial frequency band definitions operates in a thresholdfree data-driven manner.