In-silico structure prediction and domain characterization of inter alpha trypsin inhibitor heavy chain 4

Altered expression of heavy chains of inter alpha trypsin inhibitor (ITI) family along with hyaluronan have clearly been established in various chronic inflammatory diseases. In the present study, the three dimensional (3D) model construction of ITIH4 and its functional role using Ginzu server was carried out. We identified three functional domains of ITIH4 protein model and elucidated their functional role. Thus, it helped us to understand the critical role of the protein in Serum derived Hyaluronic acid Associated Protein (SHAP) complex during the inflamed condition of RA.