The AGIS Metric and Time of Test: A Replication Study

Visual Field (VF) tests and corresponding data are commonly used in clinical practices to manage glaucoma. The standard metric used to measure glaucoma severity is the Advanced Glaucoma Intervention Studies (AGIS) metric. We know that time of day when VF tests are applied can influence a patient's AGIS metric value; a previous study showed that this was the case for a data set of 160 patients. In this paper, we replicate that study using data from 2468 patients obtained from Moorfields Eye Hospital. This may provide further evidence and support of this phenomenon in a replication sense. Results did indeed show a tendency for the metric to be lower for early onset patients in the morning; equally, for advanced patients, the effect was less pronounced. We thus found support for the earlier work of Montolio et al. [4] and add to the body of evidence on the AGIS metric.