Variability Issues in Automated Hippocampal Segmentation: A Study on Out-of-the-Box Software and Multi-rater Ground Truth

In automated hippocampus segmentation, issues related to ground truth rater variability, subject variability and variability of software segmentation accuracy are investigated in the context of 3 publicly available, out-of-the-box software packages. Ground truth variability among three manual raters is controlled using a majority voting based label fusion scheme and observed subject variability underpins the importance of availability of large scale ground truth.