Battery-less modular responsive neurostimulator for prediction and abortion of epileptic seizures

An inductively-powered implantable microsystem for monitoring and treatment of intractable epilepsy is presented. The miniaturized system is comprised of two mini-boards and a power receiver coil. The first board hosts a 24-channel neurostimulator SoC developed in a 0.13μm CMOS technology and performs neural recording, electrical stimulation and onchip digital signal processing. The second board communicates recorded brain signals as well as signal processing results wirelessly, and generates different supply and bias voltages for the neurostimulator SoC and other external components. The multi-layer flexible coil receives inductively-transmitted power and sends it to the second board for power management. The system is sized at 2 × 2 × 0.7 cm
³
, weighs 6 grams, and is validated in control of chronic seizures in vivo in freely-moving rats.