Optimal Inputs For Blood Glucose Regulation Parameter Estimation

The estimation of the parameters for blood glucose regulation can be enhanced by using a glucose infusion input which is optimal in some mathematical sense. Using a linear two-compartment model, techniques are given for deriving the optimal input. Methods of extending the techniques for different performance criteria and more complex glucose regu- lation models are discussed. The results may eventually prove useful for developing new clinical tests which can differentiate the normal patient from the diabetic.