Optical measurement of glucose levels in scattering media

A method for non-invasive determination of blood glucose on the basis of selective spectral analysis of reflected from or transmitted through biological tissues containing blood is demonstrated. Our proposed algorithm is based on a discrete number of wavelengths. The wavelengths are selected such that the measurements of glucose levels can be most sensitive and such that the influences of other substances such as water, hemoglobin, skin, etc. may be minimized. A compact instrument is developed for measurement. Verifications of the algorithm are successfully accomplished using scattering solutions whose glucose concentrations varied up to 1000 mg/dl.