Neurointerface-interfaces of neuronal networks to electrical circuit

Neurointerfaces which connect the nervous system to electrical circuits are expected to play an important role in exploring the frontier of brain science. A planar electrode array (PEA) which is a useful neurointerface for observing electrical activity of cultured neuronal network is described. The developmental electrical activity changes of neuronal networks and electrical activity propagation in reconstructed visual system are observed successfully using the PEA. The possibility of formation of patterned neuronal network on the PEA are also shown using a novel cell positioning technique. The PEA is expected to play an important role in developing brain science.