Simulation and experiment on biological tissue for near infra-red (NIR) photon migration in a multi-layered model

To study the phenomenon of infrared photon migration in a multi-layered tissue is very useful in biomedical applications such as noninvasive optical monitoring of physiological parameters and the optimal dosimetry of photodynamic therapy. Multi-layered models for the research of NIR light propagation in biological tissue are established using Monte-Carlo simulation. Photon tracking and parameter correcting methods across the boundary of tissue layers with mismatched optical properties are provided. Experimental results on animal tissue are presented, and a close relationship has been found between the actual measurement and the simulation.