Bioinformatics Analysis of Integrin aVß3

Integrins are cell adhesion molecules that mediate cell-cell, cell-extracellular matrix, and cell-pathogen interaction. They play critical roles in leukocyte trafficking, migration, immunological synapse formation, costimulation, and phagocytosis. The studies of integrin structure and function help us better understanding the various pathological processes such as chronic inflammation, thrombosis and cancer metastasis. They are also significant in designing related anti-inflammatory and anti-tumor drugs. A variety of methods of bioinformatics softwares are used to analyze their protein sequences, structure, the basic chemical property of the primary structure, the secondary structure of the protein sequence and the tertiary structure of the protein homology modeling. The different evolutionary relationship of av ß subunit and ß3 subunit in different species will be also learned. After that, the biological pathways related integrin av ß3 will be mainly analyzed, to find detailed integrin avß3 pathways and the key members. This research deepens our understanding about the structure and functions of integrin av ß3, providing new insight into the treatment of related diseases.