Applying novel identification protocols to Markov models of INa

Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markov model parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in non-trivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings.