Simulation of the pacemaker created from the cardiomyocytes by reducing inward-rectifier K+ current

Cardiac conduction disorders are common diseases, to treat which, the best way by now is to implant electronic pacemakers; nevertheless, there are many disadvantages, such as limited battery life, infection and so on. Bio-pacemaker has been being expected to replace the electronic devices. This study aimed to develop a 2D model of human bio-pacemaker created from the ventricular endo-myocytes. First, the TNNP06 human ventricular model was used to investigate the automaticity of the created single pacing cell. Then the 2D model was developed by incorporating the automatic cells into the ventricular sheet in three different ways. For single pacing cell, the action potentials were stable with the period around 852ms. For 2D tissue, the pacemaker in the first way could not drive the tissue at all, while the whole ventricular sheet could be driven in the other two ways. What's more, the pacemaker paced at the same rhythm to the single auto-cell when it worked. This demonstrated that the driving force of pacemaker closely related to the conduction mode in addition to the size.