The hypothesis regarding the regenerative action of silver nanoparticles

The rationale of this paper is the silver nanoparticles' responsive behavior by activating adult stem cells of mesodermal and ectodermal in vivo origin. Reports on regeneration of hair follicles in rabbit skin, meaning an accelerated healing of surgical wounds and a process of hair follicle neogenesis, produced by subcutaneous implantation of some nanofibers functionalized with silver nanoparticles have been highlighted. Another laboratory scaled injury model of rat striated muscle, showed an enhanced histological aspect of healed muscle comparing to placebo, by using an oily nanodispersion of silver. In vitro stimulation of mesenchymal stem cells by silver nanoparticles has also been reported by the literature. However, it is noteworthy to mention that even if the silver nanoparticles do not produce mesenchymal stem differentiation in vitro, the interleukin 6 and 8 secreted by mesenchymal stem cells under the action of these nanoparticles, could accelerate the healing of cutaneous lesions. Moreover, the process of hair follicle neogenesis found in our studies would not be possible, without proliferation and differentiation of hair follicle stem cells. An assumed confirmation of the above mentioned hypothesis will open a new research direction toward silver nanoparticles, using in plastic and reconstructive surgery, degenerative diseases and anti-aging therapy. Specific histological methods concerning the responsive behavior of the stem cells in injured tissues, which are treated with pharmacological preparations containing silver nanoparticles, will be used. Taking into account the experimental studies showing a pronounced regenerative /responsive behavior of silver nanoparticles, novel pharmaceutical formulations with topic response have been synthesized.