3D multi-function bio-sphere Drosophila behavior platform

This study presents a novel "3D multi-function bio-sphere Drosophila (fruit fly) behavior platform" implemented by Micro Electro Mechanical System (MEMS) and flexible electronics technology. The 3D multi-function bio-sphere behavior platform has three merits: (1) The 3D MEMS bio-sphere provides a natural like testing environment (sphere space) for fly's behavior observation, (2) The integration of micro transducers (i.e. electric shock punisher, thermal punisher, and position sensor) enables various bio-experiments and the future potential of automatic training and recording, and (3) The transparent bio-sphere enhances the flexibility of bio-experiments through adding external visual learning targets and behavior monitoring camera. This is the first 3D Drosophila behavior training and recording platform for brain (learning and memory) experiments.