Identification of cancer-specific motifs in mimotope profiles of serum antibody repertoire

For fighting cancer earlier detection is crucial. The whole proteome can be represented by a random peptide phage display library (RPPDL). This allows to develop an early cancer detection test comparing cancer patients' and healthy donors' global peptide profiles of antibody specificities. To decrease the complexity of profiles we developed a method for transforming a list of peptides constituting the mimotope profiles to the list motifs formed by similar peptide sequences. As a result, multiple cancer-specific motifs have been identified.