Magnetic Particle Spectroscopy to monitor the behavior of magnetic nanoparticles in different physiological media

Magnetic Particle Imaging (MPI) is a promising tomographic modality using magnetic nanoparticles (MNP) as probes for diagnostic purposes in biomedicine. The MPI signal quality crucially depends on the magnetic properties of the MNP as well as on the influence of the surrounding biological environment. Therefore, different physiological parameters like pH-value, salt concentration, mobility may have distinct impact on the MPI signal performance. We used Magnetic Particle Spectroscopy, the zero-dimensional MPI, to monitor the potential MPI performance of Resovist and Feraheme MNP in different physiological media as a function of time.