Dynamic computational simulations of alternans in acute myocardial ischemia

Action potential (AP) changes occurring in ischemic myocytes predispose the myocardium to fibrillation and sudden death. Ischemia is a critical and unstable condition, so experiments are difficult to conduct at the cellular level in human. The aim of this work is to use computational models to investigate the dynamic changes in human ischemic myocardium at the cellular level.