Computational modeling supports induced pluripotent stem cell-derived cardiomyocytes reliability as a model for human LQT3

Long QT 3 (LQT3) is a specific LQT syndrome, induced by defects in the SCN5A gene, encoding for the Na
⁺
channels. Its effect is a Na
⁺
current (I
Na
) gain-of-function, resulting in a sustained late current and in an action potential (AP) duration (APD) prolongation.