Semiautomatic classification of intervertebral disc degeneration in magnetic resonance images of the spine

This article describes the development of a quantitative method for computer-aided diagnosis (CAD) of intervertebral disc degeneration according to Pfirrmann's scale, a semiquantitative scale with five degrees of degeneration, in T2-weighted magnetic resonance images of the lumbar spine. The dataset consists of images of 210 discs obtained from 42 healthy individuals. The intervertebral discs were assigned Pfirrmann's grades based on independent and blind classification. Binary masks of manually segmented discs were used to compute the centroids of the regions, estimate the curvature of the spine by polynomial fitting, normalize intensities, and extract regions of interest. Texture analysis was performed using Haralick's features and moments were computed for each disc. Classification was performed using an artificial neural network using the full vectors of attributes as well as a reduced set obtained using gradient ascent search. An average true-positive rate of 75.2% and an average area under the receiver operating characteristic curve of 0.78 indicate potential application of this technique for CAD of spinal pathology.