A digital reference object for the 3D Hoffman brain phantom for characterization of PET neuroimaging quality

We have developed a digital reference object that faithfully represents the structures in the Hoffman 3-D Brain Phantom™ from Data Spectrum Corporation. We have tested the fidelity of the DRO to the phantom by comparing the DRO to a CT scan, finding excellent agreement. We have also compared a PET simulation of the DRO to a PET scan of the phantom. The agreement between the simulated DRO and phantom PET scans was good.