Multiparametric, Flexible Microsensor Platform for Metabolic Monitoring \(In~Vivo\)

In this paper, we present a multiparametric microsensor platform for metabolic monitoring in vivo. In contrast to silicon or ceramic-based systems, the flexible, implantable polymer-based sensor strip is manufactured in a cost-effective hybrid of thin-film and laminate technology in a wafer-level process. Flexibility allows easy handling and placement in soft tissue. It comprises a microelectrode array for up to four electrochemical, amperometric micro-(bio)sensors, and an integrated reference electrode. The energy metabolism parameters glucose, lactate, and oxygen as well as the neurotransmitter glutamate were measured. The sensors allow dynamic, highly sensitive, localized, long-term, online measurement of up to four metabolic parameters with a single device. The reliable analytical performance of the sensors, stability of the reference electrode, and the multiparametric measurement are shown. The sensor can be inserted directly into the tissue for in vivo applications.