Localization control to enhance sensisitivity for small coagulated area using optimal modulartion frequency of radiation force

High intensity focused ultrasound (HIFU) treatment is one minimally invasive treatment method for cancer. Visualizing the internal treatment area of a body during HIFU treatment is required in order to achieve appropriate beam positioning and HIFU dosage. The objective of this work is to develop an ultrasound monitoring system for thermally induced coagulation. Localized motion imaging (LMI) is a monitoring method used to detect a localized mechanical response that is dependent on changes in tissue stiffness caused by thermal coagulation. In LMI, amplitude modulated (AM) HIFU causes oscillation of tissues in the HIFU focal area. The elastic modulus at a coagulated area increases and can be detected as an area with decreased oscillation amplitude., Localized control of the oscillation by changing the AM frequency was conducted to increase the detection sensitivity for small coagulated areas in porcine liver. 2 and 5 MHz transducers were employed for HIFU and imaging, respectively. The AM frequency was changed in the range from 34 to 168 Hz. The acoustic intensity of HIFU was 2.0 kW/cm2 at the focus and the exposure time was 45 s. The decrease in the amplitude of tissue oscillation at the focal point was detected within 5–10 s of HIFU exposure at the highest AM frequency. The high AM frequency is suitable for the detection of small coagulation areas or areas of initial coagulation and the small AM frequency is suitable for the size estimation of large coagulation areas.