Monitoring the thermal effects in the magnetic hyperthermia

Magnetic hyperthermia is a clinical therapy which uses the heat given by the magnetic nanoparticles (MNPs) in alternating magnetic fields for the treatment of various cancers. The control of temperature within the tumor and healthy tissues is an important step for the success of this therapy. This paper analyzes the temperature field determined by the heating of FeCrNbB systems injected within a tumor subjected to an alternating magnetic field. The temperature inside as well as outside the tumor was computed by finite element method (FEM) in a thermo-fluid model. The cooling effect produced by blood flowing in a blood vessel (BV) inside the tumor was take into account. The frequency and amplitude of magnetic field, MNPs concentration are optimized to obtain the temperature therapeutic range: 41 – 45 Celsius degrees within tumors with different sizes. The heat propagation is focused in tumor volume due to MNPs magnetic and thermal characteristics.