Acute HIV detection by viral lysate impedance spectroscopy on a microchip

Detecting acute Human Immunodeficiency Virus (HIV-1) at the point-of-care (POC) is an unmet clinical need. Current POC detection methods such as dipsticks and OraQuick detect antibodies and not the intact virus. These methods are not effective due the low concentration of antibodies [1, 2]. Infected persons with acute HIV-1 can potentially transmit the infection because they are not aware of their disease [3, 4]. Rapid and inexpensive POC detection diagnostic tool to detect acute HIV-1 can potentially have a substantial effect on preventing HIV-1 transmission through people at high risk of HIV-1.